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normal breast epithelial cell line mcf 10a  (ATCC)


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    ATCC normal breast epithelial cell line mcf 10a
    Normal Breast Epithelial Cell Line Mcf 10a, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 8147 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/normal+breast+epithelial+cell+line+mcf+10a/MCF+10A/pm41823875-66-2-13
    Average 99 stars, based on 8147 article reviews
    normal breast epithelial cell line mcf 10a - by Bioz Stars, 2026-10
    99/100 stars

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    Related Articles

    Multiple Displacement Amplification:

    Article Title: 2β-methoxy-2-deethoxyphantomolin synergistically enhances epirubicin effect against triple-negative breast cancer via targeted inhibition of AKT and HR pathways.
    Article Snippet: Enhancing the efficacy of chemotherapy in treating triple-negative breast cancer (TNBC) remains crucial.. Understanding the genes involved in cancer progression and targeted therapies may be beneficial for TNBC chemotherapy.. Here, bioinformatics analysis revealed that AKT1 and the key gene of homologous recombination (HR), RAD51, were significantly upregulated in breast cancer.

    Cell Culture:

    Article Title: Novel role of the SOX4/CSNK2A1 axis in regulating TOP2A phosphorylation in breast cancer progression
    Article Snippet: © 2025 Federation of American Societies for Experimental Biology.. Abbreviations: AUC, area under the curve; BCA, bicinchoninic acid; CCK8, Cell Counting Kit8; ChIP, chromatin immunoprecipitation; CPTAC, Clinical Proteomic Tumor Analysis Consortium; CSNK2A1, casein kinase II subunit alpha 1; FDR, false discovery rate; GEPIA, gene expression profiling interactive analysis; HE, hematoxylin and eosin; KSEA, kinasesubstrate enrichment analysis; ME, module eigengenes; PI, propidium Iodide; ROC, receiver operating characteristic; RTqPCR, realtime quantitative polymerase chain reaction; SOX4, SRYbox transcription factor 4; TCGA, The Cancer Genome Atlas; TOP2A, DNA topoisomerase II alpha; WGCNA, weighted gene coexpression network analysis.. 1Department of Biochemistry & Molecular Biology, West China School of Basic Sciences & Forensic Medicine, Sichuan University, Chengdu, China 2West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China



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    F. nucleatum induces DNA damage leading to upregulation of error prone NHEJ repair pathway. a GSEA analysis from bulk-RNA sequencing of HCC1806 xenografts with intravenous FN23726 inoculation showing activation of DNA repair pathways. b Heatmap showing relative expression of genes involved in DNA damage and repair in FN infected breast tumors. c , d Representative immunocytochemistry images showing HCC1937 ( c ) and <t>MCF10A-BRCA+/-</t> ( d ) P0 cells exposed to F. nucleatum FN23726 and stained with γH2AX and RAD51 antibodies, as indicated. DAPI is used to stain the nuclei. e Immunoblots showing the expression of DNA-PKc, XLF and Ku80 in MCF10A-BRCA+/- and HCC1937 cells exposed to F. nucleatum FN23726 for 3 h and P0 (passage 0) or P2 (passage 2) cells. f , g Representative immunocytochemistry images showing HCC1937 and MCF10A-BRCA+/- P0 ( f ) and P1 ( g ) cells exposed to F. nucleatum FN23726 and stained with pATM and pBRCA1 antibodies, as indicated. DAPI is used to stain the nuclei. (h-i) Representative immunocytochemistry images showing SUM149 ( h ) and HCC1937 ( i ) cells exposed to F. nucleatum FN23726 and stained with DAD1 and CDK4 antibodies, as indicated. DAPI is used to stain the nuclei.
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    F. nucleatum induces DNA damage leading to upregulation of error prone NHEJ repair pathway. a GSEA analysis from bulk-RNA sequencing of HCC1806 xenografts with intravenous FN23726 inoculation showing activation of DNA repair pathways. b Heatmap showing relative expression of genes involved in DNA damage and repair in FN infected breast tumors. c , d Representative immunocytochemistry images showing HCC1937 ( c ) and <t>MCF10A-BRCA+/-</t> ( d ) P0 cells exposed to F. nucleatum FN23726 and stained with γH2AX and RAD51 antibodies, as indicated. DAPI is used to stain the nuclei. e Immunoblots showing the expression of DNA-PKc, XLF and Ku80 in MCF10A-BRCA+/- and HCC1937 cells exposed to F. nucleatum FN23726 for 3 h and P0 (passage 0) or P2 (passage 2) cells. f , g Representative immunocytochemistry images showing HCC1937 and MCF10A-BRCA+/- P0 ( f ) and P1 ( g ) cells exposed to F. nucleatum FN23726 and stained with pATM and pBRCA1 antibodies, as indicated. DAPI is used to stain the nuclei. (h-i) Representative immunocytochemistry images showing SUM149 ( h ) and HCC1937 ( i ) cells exposed to F. nucleatum FN23726 and stained with DAD1 and CDK4 antibodies, as indicated. DAPI is used to stain the nuclei.
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    F. nucleatum induces DNA damage leading to upregulation of error prone NHEJ repair pathway. a GSEA analysis from bulk-RNA sequencing of HCC1806 xenografts with intravenous FN23726 inoculation showing activation of DNA repair pathways. b Heatmap showing relative expression of genes involved in DNA damage and repair in FN infected breast tumors. c , d Representative immunocytochemistry images showing HCC1937 ( c ) and <t>MCF10A-BRCA+/-</t> ( d ) P0 cells exposed to F. nucleatum FN23726 and stained with γH2AX and RAD51 antibodies, as indicated. DAPI is used to stain the nuclei. e Immunoblots showing the expression of DNA-PKc, XLF and Ku80 in MCF10A-BRCA+/- and HCC1937 cells exposed to F. nucleatum FN23726 for 3 h and P0 (passage 0) or P2 (passage 2) cells. f , g Representative immunocytochemistry images showing HCC1937 and MCF10A-BRCA+/- P0 ( f ) and P1 ( g ) cells exposed to F. nucleatum FN23726 and stained with pATM and pBRCA1 antibodies, as indicated. DAPI is used to stain the nuclei. (h-i) Representative immunocytochemistry images showing SUM149 ( h ) and HCC1937 ( i ) cells exposed to F. nucleatum FN23726 and stained with DAD1 and CDK4 antibodies, as indicated. DAPI is used to stain the nuclei.
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    normal breast epithelial cell line mcf 10 a  (ATCC)
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    F. nucleatum induces DNA damage leading to upregulation of error prone NHEJ repair pathway. a GSEA analysis from bulk-RNA sequencing of HCC1806 xenografts with intravenous FN23726 inoculation showing activation of DNA repair pathways. b Heatmap showing relative expression of genes involved in DNA damage and repair in FN infected breast tumors. c , d Representative immunocytochemistry images showing HCC1937 ( c ) and <t>MCF10A-BRCA+/-</t> ( d ) P0 cells exposed to F. nucleatum FN23726 and stained with γH2AX and RAD51 antibodies, as indicated. DAPI is used to stain the nuclei. e Immunoblots showing the expression of DNA-PKc, XLF and Ku80 in MCF10A-BRCA+/- and HCC1937 cells exposed to F. nucleatum FN23726 for 3 h and P0 (passage 0) or P2 (passage 2) cells. f , g Representative immunocytochemistry images showing HCC1937 and MCF10A-BRCA+/- P0 ( f ) and P1 ( g ) cells exposed to F. nucleatum FN23726 and stained with pATM and pBRCA1 antibodies, as indicated. DAPI is used to stain the nuclei. (h-i) Representative immunocytochemistry images showing SUM149 ( h ) and HCC1937 ( i ) cells exposed to F. nucleatum FN23726 and stained with DAD1 and CDK4 antibodies, as indicated. DAPI is used to stain the nuclei.
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    mcf10a normal breast epithelial cell lines  (ATCC)
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    ATCC mcf10a normal breast epithelial cell lines
    F. nucleatum induces DNA damage leading to upregulation of error prone NHEJ repair pathway. a GSEA analysis from bulk-RNA sequencing of HCC1806 xenografts with intravenous FN23726 inoculation showing activation of DNA repair pathways. b Heatmap showing relative expression of genes involved in DNA damage and repair in FN infected breast tumors. c , d Representative immunocytochemistry images showing HCC1937 ( c ) and <t>MCF10A-BRCA+/-</t> ( d ) P0 cells exposed to F. nucleatum FN23726 and stained with γH2AX and RAD51 antibodies, as indicated. DAPI is used to stain the nuclei. e Immunoblots showing the expression of DNA-PKc, XLF and Ku80 in MCF10A-BRCA+/- and HCC1937 cells exposed to F. nucleatum FN23726 for 3 h and P0 (passage 0) or P2 (passage 2) cells. f , g Representative immunocytochemistry images showing HCC1937 and MCF10A-BRCA+/- P0 ( f ) and P1 ( g ) cells exposed to F. nucleatum FN23726 and stained with pATM and pBRCA1 antibodies, as indicated. DAPI is used to stain the nuclei. (h-i) Representative immunocytochemistry images showing SUM149 ( h ) and HCC1937 ( i ) cells exposed to F. nucleatum FN23726 and stained with DAD1 and CDK4 antibodies, as indicated. DAPI is used to stain the nuclei.
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    F. nucleatum induces DNA damage leading to upregulation of error prone NHEJ repair pathway. a GSEA analysis from bulk-RNA sequencing of HCC1806 xenografts with intravenous FN23726 inoculation showing activation of DNA repair pathways. b Heatmap showing relative expression of genes involved in DNA damage and repair in FN infected breast tumors. c , d Representative immunocytochemistry images showing HCC1937 ( c ) and MCF10A-BRCA+/- ( d ) P0 cells exposed to F. nucleatum FN23726 and stained with γH2AX and RAD51 antibodies, as indicated. DAPI is used to stain the nuclei. e Immunoblots showing the expression of DNA-PKc, XLF and Ku80 in MCF10A-BRCA+/- and HCC1937 cells exposed to F. nucleatum FN23726 for 3 h and P0 (passage 0) or P2 (passage 2) cells. f , g Representative immunocytochemistry images showing HCC1937 and MCF10A-BRCA+/- P0 ( f ) and P1 ( g ) cells exposed to F. nucleatum FN23726 and stained with pATM and pBRCA1 antibodies, as indicated. DAPI is used to stain the nuclei. (h-i) Representative immunocytochemistry images showing SUM149 ( h ) and HCC1937 ( i ) cells exposed to F. nucleatum FN23726 and stained with DAD1 and CDK4 antibodies, as indicated. DAPI is used to stain the nuclei.

    Journal: Cell Communication and Signaling : CCS

    Article Title: A pro-carcinogenic oral microbe internalized by breast cancer cells promotes mammary tumorigenesis

    doi: 10.1186/s12964-025-02635-9

    Figure Lengend Snippet: F. nucleatum induces DNA damage leading to upregulation of error prone NHEJ repair pathway. a GSEA analysis from bulk-RNA sequencing of HCC1806 xenografts with intravenous FN23726 inoculation showing activation of DNA repair pathways. b Heatmap showing relative expression of genes involved in DNA damage and repair in FN infected breast tumors. c , d Representative immunocytochemistry images showing HCC1937 ( c ) and MCF10A-BRCA+/- ( d ) P0 cells exposed to F. nucleatum FN23726 and stained with γH2AX and RAD51 antibodies, as indicated. DAPI is used to stain the nuclei. e Immunoblots showing the expression of DNA-PKc, XLF and Ku80 in MCF10A-BRCA+/- and HCC1937 cells exposed to F. nucleatum FN23726 for 3 h and P0 (passage 0) or P2 (passage 2) cells. f , g Representative immunocytochemistry images showing HCC1937 and MCF10A-BRCA+/- P0 ( f ) and P1 ( g ) cells exposed to F. nucleatum FN23726 and stained with pATM and pBRCA1 antibodies, as indicated. DAPI is used to stain the nuclei. (h-i) Representative immunocytochemistry images showing SUM149 ( h ) and HCC1937 ( i ) cells exposed to F. nucleatum FN23726 and stained with DAD1 and CDK4 antibodies, as indicated. DAPI is used to stain the nuclei.

    Article Snippet: Breast cancer cell lines MCF7, HCC1806, HCC1937, SUM149, and normal breast epithelial cell line MCF10A were procured from the ATCC.

    Techniques: RNA Sequencing, Activation Assay, Expressing, Infection, Immunocytochemistry, Staining, Western Blot

    Cellular uptake and intracellular survival of F. nucleatum . a Graphs present flow cytometry results showing intracellular F. nucleatum after 4 h and 24 h of co-culturing with HCC1806, HCC1937 and MCF10A-BRCA+/- cells. b Representative photomicrographs showing the uptake of FM 1-43 FX tagged F. nucleatum in MCF10A-BRCA+/- cells. DAPI is used to stain the nuclei. Phalloidin (red) is utilized to stain actin filaments. c Representative photomicrographs showing the FM 1-43 FX tagged F. nucleatum co-cultured with MCF10A-BRCA+/- followed by immunostaining with anti- F. nucleatum antibody without membrane permeabilization. d Representative photomicrographs showing the intracellular survival of FM 1-43 FX tagged F. nucleatum in MCF10A-BRCA+/- cells after 2 passages

    Journal: Cell Communication and Signaling : CCS

    Article Title: A pro-carcinogenic oral microbe internalized by breast cancer cells promotes mammary tumorigenesis

    doi: 10.1186/s12964-025-02635-9

    Figure Lengend Snippet: Cellular uptake and intracellular survival of F. nucleatum . a Graphs present flow cytometry results showing intracellular F. nucleatum after 4 h and 24 h of co-culturing with HCC1806, HCC1937 and MCF10A-BRCA+/- cells. b Representative photomicrographs showing the uptake of FM 1-43 FX tagged F. nucleatum in MCF10A-BRCA+/- cells. DAPI is used to stain the nuclei. Phalloidin (red) is utilized to stain actin filaments. c Representative photomicrographs showing the FM 1-43 FX tagged F. nucleatum co-cultured with MCF10A-BRCA+/- followed by immunostaining with anti- F. nucleatum antibody without membrane permeabilization. d Representative photomicrographs showing the intracellular survival of FM 1-43 FX tagged F. nucleatum in MCF10A-BRCA+/- cells after 2 passages

    Article Snippet: Breast cancer cell lines MCF7, HCC1806, HCC1937, SUM149, and normal breast epithelial cell line MCF10A were procured from the ATCC.

    Techniques: Flow Cytometry, Staining, Cell Culture, Immunostaining, Membrane

    MCF10A-BRCA+/- cells exhibit altered functional properties as well as reduced olaparib and doxorubicin responsiveness upon F. nucleatum exposure. ( a ) Representative images show anchorage-dependent colony formation of MCF10A-BRCA+/- cells exposed to F. nucleatum followed by one (P1) or three (P3) passages. ( b ) Representative images show anchorage-independent colony formation (soft-agar colony-formation) of MCF10A-BRCA+/- cells exposed to F. nucleatum . Bar graph shows quantitative representation of the area of soft-agar colonies. N=3, Between group comparison by student’s t test. ( c ) Representative images show spheroid-migration of MCF10A-BRCA+/- cells exposed to F. nucleatum FN23726. Bar graph shows quantitative representation of distance migrated by the cells. N=3, Between group comparison by student’s t test. ( d ) Representative immunocytochemistry images showing MCF10A-BRCA+/- cells exposed to F. nucleatum FN23726 and stained with γH2AX antibodies, as indicated. DAPI is used to stain the nuclei. ( e ) Representative images of mammospheres (primary, secondary and tertiary) formed by MCF10A-BRCA+/- cells exposed to F. nucleatum FN23726. ( f ) Bar graphs show the number and area of mammospheres formed in each group. N=3, Between group comparison by student’s t test. ( g ) Representative data for ALDH1 activity in MCF10A-BRCA+/- cells exposed to F. nucleatum FN23726. ( h ) Dose response curves showing viability of MCF10A-BRCA+/-, HCC1937 and SUM149 cells exposed to F. nucleatum FN23726 (P2), in response to varying concentrations of Olaparib and Doxorubicin. Viability of cells were determined by MTT assay at 48 hours in two independent experiments with 4 replicates per group in each experiment (N=8). Dose response curves of Sham vs FN-cocultured cells was compared using 2 way ANOVA

    Journal: Cell Communication and Signaling : CCS

    Article Title: A pro-carcinogenic oral microbe internalized by breast cancer cells promotes mammary tumorigenesis

    doi: 10.1186/s12964-025-02635-9

    Figure Lengend Snippet: MCF10A-BRCA+/- cells exhibit altered functional properties as well as reduced olaparib and doxorubicin responsiveness upon F. nucleatum exposure. ( a ) Representative images show anchorage-dependent colony formation of MCF10A-BRCA+/- cells exposed to F. nucleatum followed by one (P1) or three (P3) passages. ( b ) Representative images show anchorage-independent colony formation (soft-agar colony-formation) of MCF10A-BRCA+/- cells exposed to F. nucleatum . Bar graph shows quantitative representation of the area of soft-agar colonies. N=3, Between group comparison by student’s t test. ( c ) Representative images show spheroid-migration of MCF10A-BRCA+/- cells exposed to F. nucleatum FN23726. Bar graph shows quantitative representation of distance migrated by the cells. N=3, Between group comparison by student’s t test. ( d ) Representative immunocytochemistry images showing MCF10A-BRCA+/- cells exposed to F. nucleatum FN23726 and stained with γH2AX antibodies, as indicated. DAPI is used to stain the nuclei. ( e ) Representative images of mammospheres (primary, secondary and tertiary) formed by MCF10A-BRCA+/- cells exposed to F. nucleatum FN23726. ( f ) Bar graphs show the number and area of mammospheres formed in each group. N=3, Between group comparison by student’s t test. ( g ) Representative data for ALDH1 activity in MCF10A-BRCA+/- cells exposed to F. nucleatum FN23726. ( h ) Dose response curves showing viability of MCF10A-BRCA+/-, HCC1937 and SUM149 cells exposed to F. nucleatum FN23726 (P2), in response to varying concentrations of Olaparib and Doxorubicin. Viability of cells were determined by MTT assay at 48 hours in two independent experiments with 4 replicates per group in each experiment (N=8). Dose response curves of Sham vs FN-cocultured cells was compared using 2 way ANOVA

    Article Snippet: Breast cancer cell lines MCF7, HCC1806, HCC1937, SUM149, and normal breast epithelial cell line MCF10A were procured from the ATCC.

    Techniques: Functional Assay, Comparison, Migration, Immunocytochemistry, Staining, Activity Assay, MTT Assay